付文强 副研究员
基本信息
研究方向：基于核磁共振技术研究核酸G-四链体的结构与功能
出生年月：1993年5月
常用邮箱：fwq2015@mail.ustc.edu.cn
教育与工作经历
2026.03 ~ 至今，中国科学院强磁场科学中心，副研究员
2024.01 ~ 2026.03，中国科学院强磁场科学中心，特任副研究员
2021.12 ~ 2024.01，中国科学院强磁场科学中心，博士后
2015.09 ~ 2021.12，中国科学技术大学，生物物理学，博士
2011.09 ~ 2015.06，海南大学，生物技术，学士
基金项目
主持国家自然科学基金青年基金项目（主持）
中国科学院特别科研助理项目（主持）
中国博士后站前特别资助项目（主持）
中国博士后面上资助项目（主持）
论文成果
1. Fu, WQ#; Jing, HT#; Xu, XJ.; Xu, SP; Wang, T; Hu, W.; Li, HH; Zhang, N*. Two coexisting pseudo-mirror heteromolecular telomeric G-quadruplexes in opposite loop progressions differentially recognized by a low equivalent of Thioflavin T. Nucleic Acids Research, 2021, 49 (18), 10717-10734.
2. Zhang, Y#; Fu, WQ#; Wang, YH#; Wu, AY; Zhu, ZZ; Yin, XK; Li, Y; Sun, YD; Shi, WP; Cheng, JM; Hu*, LH*; Liu, J*; Cui, J*. Inhibition of DDX5-Mediated G-Quadruplex Unwinding in the beta-Catenin 5'-UTR by Magnesium Isoglycyrrhizinate Alleviates Chemotherapy-Induced Intestinal Injury. Research, 2026, 9 (ja), 1044.
3. Liu, QQ#; Han, MR#; Wu, ZG#; Fu, WQ#; Ji, J.; Liang, QQ.; Tan, MJ; Zhai, LH; Gao, J; Shi, DQ; Jiang, Q; Sun, ZY; Lai, YP; Xu, Q; Sun, Y. DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding. Nature Aging, 2024, 4 (5), 664-680.
4. Jing, HT#; Fu, WQ#; Hu, WX; Xu, SP; Xu, XJ; He, M; Liu, YZ; Zhang, N*. NMR structural study on the self-trimerizationof d(GTTAGG) into a dynamic trimolecular G-quadruplex assembly preferentially in Nat solution with a moderate K+ tolerance. Nucleic Acids Research, 2021, 49 (4), 2306-2316.
5. Hu, WX#; Jing, HT#; Fu, WQ; Wang, ZR; Zhou, J; Zhang, N*. Conversion to Trimolecular G-Quadruplex by Spontaneous Hoogsteen Pairing-Based Strand Displacement Reaction between Bimolecular G-Quadruplex and Double G-Rich Probes. J. Am. Chem. Soc, 2023, 145 (33), 18578-18590.
6. Wan CJ, Fu WQ, Jing HT, Zhang N*. NMR solution structure of an asymmetric intermolecular leaped V-shape G-quadruplex: selective recognition of the d(G2NG3NG4) sequence motif by a short linear G-rich DNA probe. Nucleic Acids Research, 2018, 47(3), p1544-1556.
7. Bi, XM; Fu, WQ; Zhang, Na*; Wang, T*. Reassembly between two distinct G-quadruplexes. Journal of Biology, 2024, 41 (02), 25-31.
8. Zhu, T; Fu, WQ; Wang, T*. Structure and stability of interlocked G-quadruplexes formed by d( G3AG2T3G3AT) in vitro. Journal of Biology, 2021, 38 (04), 114-119.